BDBM50390404 CHEMBL2070936

SMILES Fc1ccc(cc1)N1CCN(CC1)C(=O)[C@@H]1CCCC[C@H]1C(=O)NC1(CC1)C#N

InChI Key InChIKey=GHDIYQHGVKVLJX-RTBURBONSA-N

Data  10 IC50

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50390404   

TargetCathepsin K(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50390404(CHEMBL2070936)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant cathepsin-k using Z-Phe-Arg-AMC as substrate preincubated for 15 mins measured after 1 hr by QFRET assayMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50390404(CHEMBL2070936)
Affinity DataIC50:  15nMAssay Description:Inhibition of cathepsin-kMore data for this Ligand-Target Pair
TargetCathepsin K(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50390404(CHEMBL2070936)
Affinity DataIC50:  15.8nMAssay Description:Inhibition of human recombinant cathepsin K using Z-Phe-Arg-AMC as substrate preincubated for 30 mins measured after 1 hr by quenched fluorescent res...More data for this Ligand-Target Pair